ANZSGM ASM 2017 Older peoples care through Community, Collaboration and Communication 10-12 May 2017 Rotorua New Zealand

Vasi Ngagnathan

Vasi Naganathan is an academic at the University of Sydney and a consultant Geriatrician at Concord RG Hospital. His research interests are wide including: health of older men, oral health, falls, fractures and osteoporosis, pharmacology in the older people and the application of evidence-based medicine to older people. One of the most satisfying aspect of his research is collaborating with other disciplines in doing research that has relevance to older people.


Estimating the risk of severe chemotherapy toxicity in adults ≥65 years: comparing the CARG Score with Oncologists’ estimates of toxicity

Aims: The validated CARG Toxicity Score (Hurria et al, 2011) estimates the risk of severe chemotherapy toxicity in older adults as low (score 0-5, 30% risk), intermediate (score 6-9, 52% risk) and high (score 10-23, 83% risk). We compared the risk of severe chemotherapy toxicity estimated using the CARG Score with that estimated by the oncologist. 

Methods: The CARG Toxicity Score was calculated for patients ≥65yrs prior to starting chemotherapy for a solid organ cancer (any stage). Treating oncologists independently estimated the probability of severe chemotherapy toxicity (0-100%) on 125 patients from 10 oncologists.

 Results: Median age was 72 (range 65 to 86). Most patients were male (74, 59%), having palliative chemotherapy (82, 66%) for stage IV cancer (77, 62%). The most common tumour types were colorectal (44, 35%) and lung (13, 10%). Oncologist’s estimates did not differ by CARG Score risk group (see table below). Estimated risk of severe toxicity from the CARG Score and oncologists were not correlated (r= -0.006). 

Conclusions: Oncologists’ estimates of severe chemotherapy-related toxicity differed from the risk as estimated by the CARG Score.

CARG Score Risk Group

Number of patients

Oncologist estimate of severe toxicity
(median and range)

Rate of severe toxicity expected

(Hurria et al 2011)

Low (score 0 to 5)


40% (10 to 70%)


Intermediate (score 6 to 9)


30% (3 to 80%)


High (score 10 to 19)


40% (10 to 60%)



Important Dates

Call for Abstracts open: 25th October 2016

Registration Opens: 18th November 2016

Call for Abstracts Closes: 24th February 2017

Notification of Abstracts: 20th March 2017

Close of Early Registration: 31st March 2017

Conference: 10th May 2017


Host Organisation



Australian and New Zealand Society for Geriatric Medicine (ANZSGM)

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Sydney NSW 2000, Australia

Tel: +61 2 9256 5460

Fax: +61 2 9241 3458



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